Deadline was able to attend the "Amazing Spider-Man" panel and below are some of the highlights:
Peter Parker is in high school, getting hit in the head with a ball, tardy for class, reprimanded for riding a skateboard. He gets punched by a bully who is most likely Flash Thompson. Then he turns the tables and attacks the guy. Soon he's in the principal's office with Uncle Ben (Martin Sheen), who lectures Peter about “humiliating” another boy. Points out that if it's payback it ought to feel good, but it doesn't, does it?
Gwen Stacy (Stone) moves into frame in the background. Ben asks if that's the girl on Peter's computer, then loudly says to her, “He's got you on his computer! I'm his probation officer.” Then he leaves.
Awkward moment between Peter and Gwen. “We could...or we could...” “Yeah. Either one.” They like each other.
Cut to new scene. Peter finds his dad's old work briefcase.
Puts on the old glasses in there. Sees a badge for the job at Oscorp (the company run by Norman Osborne, who was the Green Goblin in the Raimi films).
Then...a secret file. Dad had secrets.
Montage of Peter waking up not knowing his own strength, presumably after the spider-bite. Smashing his alarm clock, over-squeezing toothpaste, breaking the sink faucets.
Then he's building the web-shooters. Comically misfiring them.
New scene: he's hiding in the back seat of a car in full Spidey costume as a car thief tries to jack it. He chides the guy for looking so obviously like a car thief. They get out of the car, and Spider-man acts mock-terrified at the guy's knife. Makes fun of him while shooting webs at him, pinning him to the wall.
Voice-over of Uncle Ben says that helping the helpless is “not choice, responsibility.”
A crashed vehicle has suspicious clawmarks on it. News reports talk about an “incident,” and says one man was identified at the scene. Implied that Spider-Man is being framed for something.
Denis Leary as Gwen's cop father is interesting. He issues a warrant for Spider-Man's arrest.
A shot of injured Parker in maskless suit pleading upward.
“Dr. Connors! This is not you!” Obviously looking at The Lizard, the mutant form of Dr. Curt Connors (Rhys Ifans), but we don't see it.
Another clip is shown that reveals 'The Lizard':
Dr. Connors is addressing a group of students about his missing arm and how he intends to “cure” it. Peter brings up cross-species cellular manipulation, and Connors is impressed. Still, he leaves the room and lets Gwen take charge (she must be his assistant?)
Connors in his lab experiments on himself. His arm does grow back, but scaly.
Then we cut to two girls in a bathroom stall discussing boyfriends. The toilet drains of all water and starts to shake, then the floor caves in.
Up comes The Lizard. And he's huge.
The new Spider-Man villain Lizard, played by Rhys Ifans was shown but the footage was a Comic-Con exclusive and not to be photographed. It looks really similar to Jim Lee's drawings of Batman villain Killer Croc. Imagine a CG version for Lizard.